@article{572eb3cdde3f42039e16a54d708fba38,
title = "Quantitative MRI Differences Between Early versus Late Onset Alzheimer{\textquoteright}s Disease",
abstract = "Investigators report greater parietal tau deposition and alternate frontoparietal network involvement in early onset Alzheimer{\textquoteright}s Disease (EOAD) with onset <65 years as compared with typical late onset AD (LOAD). To determine whether clinical brain MRI volumes reflect these differences in EOAD compared with LOAD. This study investigated the clinical MRI scans of 45 persons with Clinically Probable AD with onset <65 years, and compared them to 32 with Clinically Probable AD with onset ≥65 years. Brain volumes on their T1 MRI scans were quantified with a volumetric program. Receiver operating curve analyses were performed. Persons with EOAD had significantly smaller parietal lobes (volumetric percentiles) than LOAD. Late onset Alzheimer{\textquoteright}s Disease had a smaller left putamen and hippocampus. Area Under the Curve was 96.5% with brain region delineation of EOAD compared to LOAD. This study indicates parietal atrophy less than 30% of normal on clinical MRI scans is suggestive of EOAD compared to LOAD.",
keywords = "Alzheimer{\textquoteright}s, MRI, early onset, late onset, volumetric quantification",
author = "Somayeh Meysami and Raji, {Cyrus A.} and Merrill, {David A.} and Porter, {Verna R.} and Mendez, {Mario F.}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was Supported by McLoughlin Cognitive Health Gift Fund and the Pituitary Injury Foundation. Dr Raji is supported in his research by grants from the WUSTL NIH KL2 Grant (KL2 TR000450 – ICTS Multidisciplinary Clinical Research Career Development Program), the Radiological Society of North America Research Scholar Grant and the Foundation of the American Society of Neuroradiology Boerger Research Fund for Alzheimer{\textquoteright}s Disease and Neurocognitive Disorders. Dr Mendez is PI on US National Institute on Aging Grant 1RF1AG050967. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was Supported by McLoughlin Cognitive Health Gift Fund and the Pituitary Injury Foundation. Dr Raji is supported in his research by grants from the WUSTL NIH KL2 Grant (KL2 TR000450 ? ICTS Multidisciplinary Clinical Research Career Development Program), the Radiological Society of North America Research Scholar Grant and the Foundation of the American Society of Neuroradiology Boerger Research Fund for Alzheimer?s Disease and Neurocognitive Disorders. Dr Mendez is PI on US National Institute on Aging Grant 1RF1AG050967. Publisher Copyright: {\textcopyright} The Author(s) 2021.",
year = "2021",
month = nov,
day = "28",
doi = "10.1177/15333175211055325",
language = "English",
volume = "36",
journal = "American Journal of Alzheimer's Disease and Other Dementias",
issn = "1533-3175",
}