Quantitative magnetic resonance fluorine imaging: Today and tomorrow

Junjie Chen; Gregory M. Lanza; Samuel A. Wickline

doi:10.1002/wnan.87

Quantitative magnetic resonance fluorine imaging: Today and tomorrow

Junjie Chen, Gregory M. Lanza, Samuel A. Wickline

Research output: Contribution to journal › Review article › peer-review

90 Scopus citations

Abstract

Fluorine (¹⁹F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (¹H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated ¹⁹F-containing compounds in vivo. Additionally, the MR spectra of ¹⁹F-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R₁) and the absolute quantity of molecule can be determined with ¹⁹F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative ¹⁹F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells.

Original language	English
Pages (from-to)	431-440
Number of pages	10
Journal	Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1002/wnan.87
State	Published - Jul 2010

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title = "Quantitative magnetic resonance fluorine imaging: Today and tomorrow",

abstract = "Fluorine (19F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (1H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19F-containing compounds in vivo. Additionally, the MR spectra of 19F-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R1) and the absolute quantity of molecule can be determined with 19F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells.",

author = "Junjie Chen and Lanza, {Gregory M.} and Wickline, {Samuel A.}",

year = "2010",

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T1 - Quantitative magnetic resonance fluorine imaging

T2 - Today and tomorrow

AU - Chen, Junjie

AU - Lanza, Gregory M.

AU - Wickline, Samuel A.

PY - 2010/7

Y1 - 2010/7

N2 - Fluorine (19F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (1H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19F-containing compounds in vivo. Additionally, the MR spectra of 19F-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R1) and the absolute quantity of molecule can be determined with 19F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells.

AB - Fluorine (19F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (1H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19F-containing compounds in vivo. Additionally, the MR spectra of 19F-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R1) and the absolute quantity of molecule can be determined with 19F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells.

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JO - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

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Quantitative magnetic resonance fluorine imaging: Today and tomorrow

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