Quantitative magnetic resonance fluorine imaging: Today and tomorrow

Junjie Chen, Gregory M. Lanza, Samuel A. Wickline

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


Fluorine (19F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (1H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19F-containing compounds in vivo. Additionally, the MR spectra of 19F-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R1) and the absolute quantity of molecule can be determined with 19F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells.

Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number4
StatePublished - Jul 2010


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