Quantitative Label-Free Proteomics for Discovery of Biomarkers in Cerebrospinal Fluid: Assessment of Technical and Inter-Individual Variation

Keyphrases

• Cerebrospinal Fluid 100%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 100%
• Technical Variability 100%
• Inter-individual Variation 100%
• Label-free Proteomics 100%
• Fluid Assessment 100%
• Biomarker Discovery 50%
• Aliquot 50%
• Cerebrospinal Fluid Protein 50%
• NanoLC 50%
• Alzheimer's Disease 25%
• Control Subjects 25%
• Cerebrospinal Fluid Biomarkers 25%
• Pearson Correlation 25%
• Neurodegenerative Diseases 25%
• Proteome 25%
• Diagnosis Treatment 25%
• Coefficient of Variation 25%
• Neurological Diseases 25%
• Label-free 25%
• Cognitively Normal 25%
• Inter-individual Variability 25%
• LC-MS Analysis 25%
• Keratin 25%
• Clinical Group 25%
• Unique Peptide 25%
• Low Protein 25%
• Ion Current 25%
• Ion Chromatogram 25%
• Oxidized Methionine 25%
• Label-free LC-MS 25%
• Unsupervised Clustering 25%
• Charged Groups 25%
• Reparable 25%
• Biomarker Characteristics 25%
• Sample Comparison 25%
• Peptide Quantification 25%

Biochemistry, Genetics and Molecular Biology

• Liquid 100%
• Liquid Chromatography-Mass Spectrometry 100%
• Proteomics 100%
• Fractionation 42%
• Tandem Mass Spectrometry 28%
• Biomarker Discovery 28%
• Protein Cerebrospinal Fluid Level 28%
• Proteome 14%
• Ion Current 14%
• Methionine 14%
• Keratin 14%