Quantitative in vivo autoradiography with positron emission tomography

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


The emergence of positron emission tomography (PET) in the biomedical environment provides a unique new tool for sophisticated clinical investigation. The potential of the technique is obvious. PET should provide unique new information on the biochemistry and physiology of the human central nervous system in health and disease. Such information can provide a valuable interface between basic science studies in simple systems and the in vivo condition in man, which most investigators, whatever their tools, are striving to understand. The requirements for the successful implementation of PET may not be so obvious. It may be clear to most that expensive and complicated machinery including cyclotrons, imaging devices and computers are a necessary foundation, but no so clear that a critical mass of diverse human talents must be closely coordinated in order to make the full potential of PET a reality in the biochemical environment. Successful implementation of PET, if achieved, will represent a truly collaborative effort among physicists, chemists, mathematicians, and neurobiologists who share in common the desire to develop and implement quantitative techniques for the study of brain biochemistry and physiology in man.

Original languageEnglish
Pages (from-to)47-68
Number of pages22
JournalBrain Research
Issue number1 , Reviews 1/1
StatePublished - Jan 1 1979


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