Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner

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15 Scopus citations

Abstract

Positron emission tomography (PET) with15O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function that is obtained invasively by sampling blood from an artery. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative15O-PET imaging. We then compared hemodynamic PET imaging performed on a PET/MR hybrid scanner against a conventional PETonly scanner.We demonstrated the proposed imaging-based technique was able to generate brain hemodynamic parameter measurements in strong agreement with the traditional arterial sampling based approach. We also demonstrated that quantitative15O-PET imaging can be successfully implemented on a PET/MR hybrid scanner.

Original languageEnglish
Pages (from-to)1435-1446
Number of pages12
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number4
DOIs
StatePublished - 2017

Keywords

  • Arterial input function
  • Cerebral blood flow
  • Cerebral metabolic rate of oxygen
  • Positron emission tomography

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