Quantitative evaluation of systematic imaging error due to uncertainty in tissue optical properties in high-density diffuse optical tomography

Yuxuan Zhan, Adam Eggebrecht, Hamid Dehghani, Joseph Culver

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

In MRI-guided diffuse optical tomography of the human brain function, three-dimensional anatomical head model consisting of up to five segmented tissue types can be specified. With disregard to misclassification between different tissues, uncertainty in the optical properties of each tissue type becomes the dominant cause of systematic error in image reconstruction. In this study we present a quantitative evaluation of image resolution dependence due to such uncertainty. Our results show that given a head model which provides a realistic description of its tissue optical property distribution, high-density diffuse optical tomography with cortically constrained image reconstruction are capable of detecting focal activation up to 21.81 mm below the human scalp at an imaging quality better than or equal to 1.0 cm in localization error and 1.0 cm3 in FVHM with a tolerance of uncertainty in tissue optical properties between +15% and -20%.

Original languageEnglish
Title of host publicationOptical Tomography and Spectroscopy of Tissue IX
DOIs
StatePublished - May 12 2011
EventOptical Tomography and Spectroscopy of Tissue IX - San Francisco, CA, United States
Duration: Jan 23 2011Jan 26 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7896
ISSN (Print)1605-7422

Conference

ConferenceOptical Tomography and Spectroscopy of Tissue IX
CountryUnited States
CitySan Francisco, CA
Period01/23/1101/26/11

Keywords

  • diffuse optical tomography
  • image quality
  • medical imaging
  • optical neuroimaging
  • tissue optical properties

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    Zhan, Y., Eggebrecht, A., Dehghani, H., & Culver, J. (2011). Quantitative evaluation of systematic imaging error due to uncertainty in tissue optical properties in high-density diffuse optical tomography. In Optical Tomography and Spectroscopy of Tissue IX [78960O] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7896). https://doi.org/10.1117/12.873746