TY - JOUR
T1 - Quantitative D2 dopamine receptor PET and structural MRI changes in late-onset schizophrenia
AU - Pearlson, Godfrey D.
AU - Tune, Larry E.
AU - Wong, Dean F.
AU - Aylward, Elizabeth H.
AU - Barta, Patrick E.
AU - Powers, Richard E.
AU - Tien, Allen Y.
AU - Chase, Gary A.
AU - Harris, Gordon J.
AU - Rabins, Peter V.
PY - 1993
Y1 - 1993
N2 - Late-onset schizophrenia (LOS) is likely a syndrome of diverse etiology. In a series of related studies, we compared LOS patients with normal controls, elderly patients with early-onset schizophrenia (EOS), and Alzheimer's disease patients, using magnetic resonance imaging (MRI) and neuroreceptor positron emission tomography measures, which had previously been reported to be abnormal in EOS. EOS and LOS patients showed similar MRI changes. LOS drug-naive patients had elevated Bmax (receptor density) values for dopamine D2 receptors compared with age and gender norms, a phenomenon previously reported by our group in young schizophrenia patients.
AB - Late-onset schizophrenia (LOS) is likely a syndrome of diverse etiology. In a series of related studies, we compared LOS patients with normal controls, elderly patients with early-onset schizophrenia (EOS), and Alzheimer's disease patients, using magnetic resonance imaging (MRI) and neuroreceptor positron emission tomography measures, which had previously been reported to be abnormal in EOS. EOS and LOS patients showed similar MRI changes. LOS drug-naive patients had elevated Bmax (receptor density) values for dopamine D2 receptors compared with age and gender norms, a phenomenon previously reported by our group in young schizophrenia patients.
UR - http://www.scopus.com/inward/record.url?scp=0027332208&partnerID=8YFLogxK
U2 - 10.1093/schbul/19.4.783
DO - 10.1093/schbul/19.4.783
M3 - Article
C2 - 8303227
AN - SCOPUS:0027332208
SN - 0586-7614
VL - 19
SP - 783
EP - 795
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 4
ER -