Quantitative demonstration of dipyridamole‐induced coronary steal and alteration by angioplasty in man: Analysis by simultaneous, continuous dual doppler spectral flow velocity

Morton J. Kern, Thomas Wolford, Thomas J. Donohue, Richard G. Bach, Frank V. Aguirre, Eugene A. Caracciolo, Michael S. Flynn

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In the course of studying the effects of coronary angioplasty on branch vessel flow using two Doppler flow velocity guidewires, we quantitated simultaneous blood flow responses proximal and distal to a stenosis. The alterations of flow documented a horizontal epicardial steal induced during dipyridamole hyperemia, hyperemic flow reversal by intravenous aminophylline, and subsequent normalization of distal hyperemia after endoluminal enlargement by successful angioplasty. The quantitative physiology of the patient described here confirms one postulated mechanism of abnormal myocardial perfusion stress scintigraphy. Continuous dual flowire spectral coronary flow determinations appear to be a valuable method in verifying postulated mechanisms of various pharmacologic and mechanical stimuli influencing coronary blood flow in patients with atherosclerotic coronary artery disease. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalCatheterization and cardiovascular diagnosis
Volume29
Issue number4
DOIs
StatePublished - Aug 1993
Externally publishedYes

Keywords

  • Dipyridamol
  • coronary blood flow velocity
  • coronary hyperemia

Fingerprint Dive into the research topics of 'Quantitative demonstration of dipyridamole‐induced coronary steal and alteration by angioplasty in man: Analysis by simultaneous, continuous dual doppler spectral flow velocity'. Together they form a unique fingerprint.

  • Cite this