TY - JOUR
T1 - Quantitative BOLD
T2 - Mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: Default state
AU - He, Xiang
AU - Yablonskiy, Dmitriy A.
PY - 2007/1
Y1 - 2007/1
N2 - Since Ogawa et al. (Proc Natl Acad Sci USA 1990;87:9868-9872) made the fundamental discovery of blood oxygenation level-dependent (BOLD) contrast in MRI, most efforts have been directed toward the study of dynamic BOLD (i.e., temporal changes in the MRI signal during changes in brain activity). However, very little progress has been made in elucidating the nature of BOLD contrast during the resting or baseline state of the brain, which is important for understanding normal human performance because it accounts for most of the enormous energy budget of the brain. It is also crucial for deciphering the consequences of baseline-state impairment by cerebral vascular diseases. The objective of this study was to develop a BOLD MR-based method that allows quantitative evaluation of tissue hemodynamic parameters, such as the blood volume, deoxyhemoglobin concentration, and oxygen extraction fraction (OEF). The proposed method, which we have termed quantitative BOLD (qBOLD), is based on an MR signal model that incorporates prior knowledge about brain tissue composition and considers signals from gray matter (GM), white matter (WM), cerebrospinal fluid (CSF), and blood. A 2D gradient-echo sampling of spin-echo (GESSE) pulse sequence is used for the acquisition of the MRI signal. The method is applied to estimate the hemodynamic parameters of the normal human brain in the baseline state.
AB - Since Ogawa et al. (Proc Natl Acad Sci USA 1990;87:9868-9872) made the fundamental discovery of blood oxygenation level-dependent (BOLD) contrast in MRI, most efforts have been directed toward the study of dynamic BOLD (i.e., temporal changes in the MRI signal during changes in brain activity). However, very little progress has been made in elucidating the nature of BOLD contrast during the resting or baseline state of the brain, which is important for understanding normal human performance because it accounts for most of the enormous energy budget of the brain. It is also crucial for deciphering the consequences of baseline-state impairment by cerebral vascular diseases. The objective of this study was to develop a BOLD MR-based method that allows quantitative evaluation of tissue hemodynamic parameters, such as the blood volume, deoxyhemoglobin concentration, and oxygen extraction fraction (OEF). The proposed method, which we have termed quantitative BOLD (qBOLD), is based on an MR signal model that incorporates prior knowledge about brain tissue composition and considers signals from gray matter (GM), white matter (WM), cerebrospinal fluid (CSF), and blood. A 2D gradient-echo sampling of spin-echo (GESSE) pulse sequence is used for the acquisition of the MRI signal. The method is applied to estimate the hemodynamic parameters of the normal human brain in the baseline state.
KW - BOLD
KW - Brain hemodynamic
KW - Brain metabolism
KW - OEF
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=33846085587&partnerID=8YFLogxK
U2 - 10.1002/mrm.21108
DO - 10.1002/mrm.21108
M3 - Article
C2 - 17191227
AN - SCOPUS:33846085587
SN - 0740-3194
VL - 57
SP - 115
EP - 126
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 1
ER -