Quantitative assessment of alterations in regional left ventricular contractility with color-coded tissue Doppler echocardiography: Comparison with sonomicrometry and pressure-volume relations

John Gorcsan, David P. Strum, William A. Mandarino, Vijay K. Gulati, Michael R. Pinsky

Research output: Contribution to journalArticle

291 Scopus citations

Abstract

Background: Tissue Doppler imaging (TDI) is a novel method of color- coding myocardial velocity on-line. The objective of the present study was to evaluate endocardial velocity with TDI as a method of objectively quantifying alterations in regional contractility over a wide range induced by inotropic modulation. Methods and Results: Myocardial length crystals were used to simultaneously assess regional left ventricular (LV) function, and high- fidelity pressure and conductance catheters were used to assess global LV contractility by pressure-volume relations in nine open-chest dogs. Mid-LV M- mode and two-dimensional color TDI images were recorded during control and inotropic modulation stages with dobutamine and esmolol. Predicted significant increases in TDI indices occurred with dobutamine: peak systolic velocity of 4.41±1.07 to 6.67±1.07 cm/s*, systolic time-velocity integral (TVI) of 0.43±0.12 to 0.62±0.10 cm*, and diastolic TVI of 0.49±0.11 to 0.71±0.17 cm*. Opposing significant decreases occurred with esmolol: peak systolic velocity of 4.46±0.94 to 2.31±0.81 cm/s*, systolic TVI of 0.47±0.12 to 0.19±0.11 cm*, and diastolic TVI of 0.55±0.11 to 0.33±0.11 cm* (*all P<.001 versus control). Changes in TDI peak systolic velocity were correlated with changes in fractional shortening (r=.88) and shortening velocity (r=.87) by sonomicrometry. Changes in TDI peak velocity from multiple mid-LV sites also correlated significantly with maximal elastance (r=.85±.04) from pressure-volume relations. Conclusions: TDI measures reflect directional and incremental alterations in regional and global LV contractility and have the potential to quantify regional LV function.

Original languageEnglish
Pages (from-to)2423-2433
Number of pages11
JournalCirculation
Volume95
Issue number10
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • dynamics
  • echocardiography
  • imaging
  • mechanics
  • myocardium

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