Quantitation of T2' anisotropic effects on magnetic resonance bone mineral density measurement

Dmitriy A. Yablonskiy, William R. Reinus, Helmut Stark, E. Mark Haacke

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


In this paper, the authors quantitate the anisotropy of susceptibility effects in an uniaxial trabecular bone model and show its relevance to clinical MR bone mineral density measurements. A physical model is described that quantitates the anisotropic MR behavior of uniaxial trabecular bone. To test the model, a phantom of parallel polyethylene filaments was scanned every 15°between 0°and 90°with respect to the system's main magnetic field (B̄0). The distal radial metaphysis of a healthy female volunteer was scanned in orthogonal projections. The signal from each phantom image and each radial image was separated in a pixel-wise fashion into R2 and R2' maps. AS predicted, R2' relaxation showed anisotropic behavior and changed according to sin2 (θ), confirming that columnar structures parallel with B̄0 will cause no MR susceptibility effects. Scans of the distal radius showed that R2' relaxation was twice as great with the forearm perpendicular to B̄0 as when it was parallel to it, demonstrating different contributions from struts and columns. For both phantom and radial bone scans, R2 relaxation was isotropic and did not change with object orientation.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Feb 1997


  • MR susceptibility effects
  • bone mineral density
  • osteoporosis


Dive into the research topics of 'Quantitation of T2' anisotropic effects on magnetic resonance bone mineral density measurement'. Together they form a unique fingerprint.

Cite this