Quantifying vessel material properties using mri under pressure condition and mri-based fsi mechanical analysis for human atherosclerotic plaques

Chun Yang, Xueying Huang, Jie Zheng, Pamela K. Woodard, Dalin Tang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. Mechanical image analysis using MRI-based models with fluid-structure interactions (FSI) and MRI-determined material properties may improve the accuracy of plaque vulnerability assessment and rupture predictions. A plaque-phantom was set up to acquire plaque MR images under pressurized conditions. The 3D nonlinear modified Mooney-Rivlin (M-R) model was used to describe the material properties with parameters selected to fit the MRI data. The Navier-Stokes equations were used as the governing equations for the flow model. The fully-coupled FSI models were solved by ADINA. Our results indicate that doubling parameter values in the M-R model led to 12.5% decrease in structure maximum principal stress (Stress-P1) and 48% decrease in maximum principal strain (Strain-P1). Flow maximum shear stress (MSS) was almost unchanged. Results from a modified carotid plaque with 70% stenosis severity (by diameter) showed that Stress-P1 at the plaque throat from the wall-only model is 145% higher than that from the FSI model. MSS from a flow-only model is about 40% higher than that from the FSI model. This approach has the potential to develop non-invasive patient screening and diagnosis methods in clinical applications.

Original languageEnglish
Title of host publicationProceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Applied Mechanics Division
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Print)0791837904, 9780791837900
DOIs
StatePublished - Jan 1 2006
Event2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Chicago, IL, United States
Duration: Nov 5 2006Nov 10 2006

Publication series

NameAmerican Society of Mechanical Engineers, Applied Mechanics Division, AMD
ISSN (Print)0160-8835

Conference

Conference2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006
CountryUnited States
CityChicago, IL
Period11/5/0611/10/06

Keywords

  • Artery
  • Fluid-structure interactions
  • Vessel elasticity

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