TY - JOUR
T1 - Quantifying myocardial oxygenation with cardiac magnetic resonance imaging
AU - Muccigrosso, David J.
AU - Zheng, Jie
PY - 2012
Y1 - 2012
N2 - Myocardial ischemia, resulting from imbalance in myocardial oxygen supply and demand, can be quantitatively assessed by positron emission tomography (PET) with absolute measures of myocardial blood flow and oxygen consumption rate (MVO 2). Cardiac Magnetic Resonance (CMR) has notable advantages over PET, with no radiation, high spatial resolution, faster scan times, and excellent soft tissue contrast. We have developed and validated new quantitative CMR oximetry techniques, including measurements of hyperemic myocardial oxygen extraction fraction and MVO 2 through Fick's Law. These may lead to a new understanding of roles of myocardial microcirculation in myocardial ischemia. Other cardiac oximetry methods for directly quantifying MVO 2 with 17O-labelled water are also under investigation. Quantitative CMR oximetry is a promising, non-invasive, non-radiation approach for exploring the myocardial metabolism's role in cardiac patients.
AB - Myocardial ischemia, resulting from imbalance in myocardial oxygen supply and demand, can be quantitatively assessed by positron emission tomography (PET) with absolute measures of myocardial blood flow and oxygen consumption rate (MVO 2). Cardiac Magnetic Resonance (CMR) has notable advantages over PET, with no radiation, high spatial resolution, faster scan times, and excellent soft tissue contrast. We have developed and validated new quantitative CMR oximetry techniques, including measurements of hyperemic myocardial oxygen extraction fraction and MVO 2 through Fick's Law. These may lead to a new understanding of roles of myocardial microcirculation in myocardial ischemia. Other cardiac oximetry methods for directly quantifying MVO 2 with 17O-labelled water are also under investigation. Quantitative CMR oximetry is a promising, non-invasive, non-radiation approach for exploring the myocardial metabolism's role in cardiac patients.
KW - Ischemia
KW - Magnetic resonance imaging
KW - Oxygen consumption
KW - Oxygen extraction
UR - http://www.scopus.com/inward/record.url?scp=84860701221&partnerID=8YFLogxK
U2 - 10.2174/1874347101206010039
DO - 10.2174/1874347101206010039
M3 - Article
AN - SCOPUS:84860701221
SN - 1874-3471
VL - 6
SP - 39
EP - 44
JO - Open Medical Imaging Journal
JF - Open Medical Imaging Journal
IS - SPEC.ISS.1
ER -