TY - JOUR
T1 - Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study
T2 - research methods and cohort profile
AU - Kwan, Marilyn L.
AU - Miglioretti, Diana L.
AU - Bowles, Erin J.A.
AU - Weinmann, Sheila
AU - Greenlee, Robert T.
AU - Stout, Natasha K.
AU - Rahm, Alanna Kulchak
AU - Alber, Susan A.
AU - Pequeno, Priscila
AU - Moy, Lisa M.
AU - Stewart, Carly
AU - Fong, Cindy
AU - Jenkins, Charisma L.
AU - Kohnhorst, Diane
AU - Luce, Casey
AU - Mor, Joanne M.
AU - Munneke, Julie R.
AU - Prado, Yolanda
AU - Buth, Glen
AU - Cheng, Stephanie Y.
AU - Deosaransingh, Kamala A.
AU - Francisco, Melanie
AU - Lakoma, Matthew
AU - Martinez, Yannica Theda
AU - Theis, Mary Kay
AU - Marlow, Emily C.
AU - Kushi, Lawrence H.
AU - Duncan, James R.
AU - Bolch, Wesley E.
AU - Pole, Jason D.
AU - Smith-Bindman, Rebecca
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/5
Y1 - 2022/5
N2 - Purpose: The Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study is quantifying the association between cumulative radiation exposure from fetal and/or childhood medical imaging and subsequent cancer risk. This manuscript describes the study cohorts and research methods. Methods: The RIC Study is a longitudinal study of children in two retrospective cohorts from 6 U.S. healthcare systems and from Ontario, Canada over the period 1995–2017. The fetal-exposure cohort includes children whose mothers were enrolled in the healthcare system during their entire pregnancy and followed to age 20. The childhood-exposure cohort includes children born into the system and followed while continuously enrolled. Imaging utilization was determined using administrative data. Computed tomography (CT) parameters were collected to estimate individualized patient organ dosimetry. Organ dose libraries for average exposures were constructed for radiography, fluoroscopy, and angiography, while diagnostic radiopharmaceutical biokinetic models were applied to estimate organ doses received in nuclear medicine procedures. Cancers were ascertained from local and state/provincial cancer registry linkages. Results: The fetal-exposure cohort includes 3,474,000 children among whom 6,606 cancers (2394 leukemias) were diagnosed over 37,659,582 person-years; 0.5% had in utero exposure to CT, 4.0% radiography, 0.5% fluoroscopy, 0.04% angiography, 0.2% nuclear medicine. The childhood-exposure cohort includes 3,724,632 children in whom 6,358 cancers (2,372 leukemias) were diagnosed over 36,190,027 person-years; 5.9% were exposed to CT, 61.1% radiography, 6.0% fluoroscopy, 0.4% angiography, 1.5% nuclear medicine. Conclusion: The RIC Study is poised to be the largest study addressing risk of childhood and adolescent cancer associated with ionizing radiation from medical imaging, estimated with individualized patient organ dosimetry.
AB - Purpose: The Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study is quantifying the association between cumulative radiation exposure from fetal and/or childhood medical imaging and subsequent cancer risk. This manuscript describes the study cohorts and research methods. Methods: The RIC Study is a longitudinal study of children in two retrospective cohorts from 6 U.S. healthcare systems and from Ontario, Canada over the period 1995–2017. The fetal-exposure cohort includes children whose mothers were enrolled in the healthcare system during their entire pregnancy and followed to age 20. The childhood-exposure cohort includes children born into the system and followed while continuously enrolled. Imaging utilization was determined using administrative data. Computed tomography (CT) parameters were collected to estimate individualized patient organ dosimetry. Organ dose libraries for average exposures were constructed for radiography, fluoroscopy, and angiography, while diagnostic radiopharmaceutical biokinetic models were applied to estimate organ doses received in nuclear medicine procedures. Cancers were ascertained from local and state/provincial cancer registry linkages. Results: The fetal-exposure cohort includes 3,474,000 children among whom 6,606 cancers (2394 leukemias) were diagnosed over 37,659,582 person-years; 0.5% had in utero exposure to CT, 4.0% radiography, 0.5% fluoroscopy, 0.04% angiography, 0.2% nuclear medicine. The childhood-exposure cohort includes 3,724,632 children in whom 6,358 cancers (2,372 leukemias) were diagnosed over 36,190,027 person-years; 5.9% were exposed to CT, 61.1% radiography, 6.0% fluoroscopy, 0.4% angiography, 1.5% nuclear medicine. Conclusion: The RIC Study is poised to be the largest study addressing risk of childhood and adolescent cancer associated with ionizing radiation from medical imaging, estimated with individualized patient organ dosimetry.
KW - Childhood cancer
KW - Childhood leukemia
KW - Computed tomography
KW - Ionizing radiation
KW - Medical imaging
KW - Retrospective cohort study
UR - http://www.scopus.com/inward/record.url?scp=85124109200&partnerID=8YFLogxK
U2 - 10.1007/s10552-022-01556-z
DO - 10.1007/s10552-022-01556-z
M3 - Article
C2 - 35107724
AN - SCOPUS:85124109200
SN - 0957-5243
VL - 33
SP - 711
EP - 726
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 5
ER -