Quantification of Tumor Vascularity with Contrast-Enhanced Sonography: Correlation with Magnetic Resonance Imaging and Fluorodeoxyglucose Autoradiography in an Implanted Tumor

Arthur C. Fleischer, Edwin F. Donnelly, Ryan J. Grippo, Amy S. Black, Dennis E. Hallahan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objective. To correlate the quantitated tumor vascularity of implanted murine tumors as depicted by contrast-enhanced sonography with estimates made with magnetic resonance imaging and with estimates of the percentage of viable (metabolically active) tumor as depicted by fluorodeoxyglucose autoradiography. Methods. Implanted tumors in 10 mice were imaged with contrast-enhanced sonography, magnetic resonance imaging, and fluorodeoxyglucose autoradiography. Tumor vascularity was estimated with each modality and compared with the percentage of viable tumor. Results. Quantitated estimates of tumor vascularity with contrast-enhanced sonography closely correlated (r = 0.95) with estimates made by magnetic resonance imaging and with the percentage of viable tumor (r = 0.93) as depicted by fluorodeoxyglucose autoradiography. Conclusions. Contrast-enhanced sonography accurately depicts tumor vascularity in these implanted tumors. Tumor vascularity correlated with the amount of metabolically active tumor.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalJournal of Ultrasound in Medicine
Volume23
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Contrast-enhanced sonography
  • Fluorodeoxyglucose autoradiography
  • Magnetic resonance imaging
  • Tumor vascularity

Fingerprint Dive into the research topics of 'Quantification of Tumor Vascularity with Contrast-Enhanced Sonography: Correlation with Magnetic Resonance Imaging and Fluorodeoxyglucose Autoradiography in an Implanted Tumor'. Together they form a unique fingerprint.

  • Cite this