Quantification of stenotic mitral valve area with magnetic resonance imaging and comparison with Doppler ultrasound

Shiow Jiuan Lin, Peggy A. Brown, Mary P. Watkins, Todd A. Williams, Katherine A. Lehr, Wei Liu, Gregory M. Lanza, Samuel A. Wickline, Shelton D. Caruthers

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Objectives The purpose of this study was to evaluate the reliability of the pressure half-time (PHT) method for estimating mitral valve areas (MVAs) by velocity-encoded cardiovascular magnetic resonance (VE-CMR) and to compare the method with paired Doppler ultrasound. Background The pressure half-time Doppler echocardiography method is a practical technique for clinical evaluation of mitral stenosis. As CMR continues evolving as a routine clinical tool, its use for estimating MVA requires thorough evaluation. Methods Seventeen patients with mitral stenosis underwent echocardiography and CMR. Using VE-CMR, MVA was estimated by PHT method. Additionally, peak E and peak A velocities were defined. Interobserver repeatability of VE-CMR was evaluated. Results By Doppler, MVAs ranged from 0.87 to 4.49 cm 2; by CMR, 0.91 to 2.70 cm 2, correlating well between modalities (r = 0.86). The correlation coefficient for peak E and peak A between modalities was 0.81 and 0.89, respectively. Velocity-encoded CMR data analysis provided robust, repeatable estimates of peak E, peak A, and MVA (r = 0.99, 0.99, and 0.96, respectively). Conclusions Velocity-encoded cardiovascular magnetic resonance can be used routinely as a robust tool to quantify MVA via mitral flow velocity analysis with PHT method.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalJournal of the American College of Cardiology
Issue number1
StatePublished - Jul 7 2004


  • AF
  • CMR
  • MS
  • MVA
  • PHT
  • ROI
  • V
  • atrial fibrillation
  • cardiovascular magnetic resonance
  • mitral stenosis
  • mitral valve area
  • pressure half-time
  • region of interest
  • velocity encoding (maximum) value


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