TY - JOUR
T1 - Quantification of myocardial glucose utilization by PET and 1-carbon-11-glucose
AU - Herrero, Pilar
AU - Weinheimer, Carla J.
AU - Dence, Carmen
AU - Oellerich, William F.
AU - Gropler, Robert J.
PY - 2002
Y1 - 2002
N2 - Background. Measurements of the rate of myocardial glucose utilization (rMGU) play a key role in the assessment of alterations in myocardial substrate metabolism in normal and abnormal cardiac states. In this study we determined whether rMGU could be quantified by positron emission tomography (PET) and 1-carbon-11-glucose. Methods and Results. Twenty dogs were studied with a variety of interventions including fasting (n = 5), hyperinsulinemic-euglycemic clamp at rest (n = 6), clamp and phenylephrine (n = 5), and clamp and dobutamine (n = 4). Measurements of myocardial blood flow and rMGU were made by PET with oxygen-15-water and 1-C-11-glucose, respectively. Arterial-coronary sinus sampling was performed to measure rMGU by the Fick method. Values for rMGU ranged from 50 to 2436 nmol/g/min. Myocardial 1-C-11-glucose images of high quality were obtained. There was a close and direct correlation between values for rMGU measured by PET and those measured directly (y = 0.86x + 112, r = 0.98, P <.0001). The coefficient of variation for the regional estimates of rMGU ranged from 11.3% ± 7.4% during clamp at rest to 16.3% ± 8.4% during clamp with phenylephrine. Conclusions. It now appears possible to quantify myocardial glucose utilization by PET with 1-C-11-glucose. This method should become a valuable tool in the assessment of alterations in myocardial glucose metabolism in both normal and abnormal myocardium.
AB - Background. Measurements of the rate of myocardial glucose utilization (rMGU) play a key role in the assessment of alterations in myocardial substrate metabolism in normal and abnormal cardiac states. In this study we determined whether rMGU could be quantified by positron emission tomography (PET) and 1-carbon-11-glucose. Methods and Results. Twenty dogs were studied with a variety of interventions including fasting (n = 5), hyperinsulinemic-euglycemic clamp at rest (n = 6), clamp and phenylephrine (n = 5), and clamp and dobutamine (n = 4). Measurements of myocardial blood flow and rMGU were made by PET with oxygen-15-water and 1-C-11-glucose, respectively. Arterial-coronary sinus sampling was performed to measure rMGU by the Fick method. Values for rMGU ranged from 50 to 2436 nmol/g/min. Myocardial 1-C-11-glucose images of high quality were obtained. There was a close and direct correlation between values for rMGU measured by PET and those measured directly (y = 0.86x + 112, r = 0.98, P <.0001). The coefficient of variation for the regional estimates of rMGU ranged from 11.3% ± 7.4% during clamp at rest to 16.3% ± 8.4% during clamp with phenylephrine. Conclusions. It now appears possible to quantify myocardial glucose utilization by PET with 1-C-11-glucose. This method should become a valuable tool in the assessment of alterations in myocardial glucose metabolism in both normal and abnormal myocardium.
KW - Glucose
KW - Metabolism
KW - Myocardium
KW - Tomography
UR - http://www.scopus.com/inward/record.url?scp=0036188245&partnerID=8YFLogxK
U2 - 10.1067/mnc.2001.120635
DO - 10.1067/mnc.2001.120635
M3 - Article
C2 - 11845124
AN - SCOPUS:0036188245
VL - 9
SP - 5
EP - 14
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
IS - 1
ER -