Quality of life outcomes in patients participating in the CALGB 30610 trial (CALGB 70702): Alliance

Apar K. Ganti, Briant Fruth, Andreas Rimner, Saiama Waqar, Michael D. Mix, W. Jeffrey Petty, Thomas E. Stinchcombe, Everett E. Vokes, Jeffrey A. Bogart, Amylou C. Dueck

Research output: Contribution to journalArticlepeer-review

Abstract

Background: CALGB 30610 trial demonstrated that once daily thoracic radiotherapy (TRT) was not superior compared to standard twice daily TRT, in patients with limited stage small cell lung cancer. Quality of life outcomes may help oncologists decide the best treatment approach. Methods: A total of 417 patients on CALGB 30610 participated in the quality-of-life substudy (CALGB 70702), which included the FACT Trial Outcome Index-Lung Cancer (FACT-L TOI), FACT-Esophageal Cancer (FACT-E) Eating and Swallowing Indices, ECOG Acute Esophagitis Scale, Hospital Anxiety and Depression Scale (HADS), difficulty swallowing, EQ-5D, and treatment convenience assessment at baseline, 3, 5, 7, 12, 26, and 52 weeks after starting TRT. Primary end points included FACT-L TOI and FACT-E at 12 weeks. Mean changes from baseline were compared between arms using general linear mixed models. Results: FACT-L worsening was more in the twice daily arm at week 3 (–1.0 vs. –7.0). FACT-L TOI worsening was less at week 3 (–2.9 vs. –7.6) and greater at week 12 (–7.6 vs. –2.8) in the once daily arm. The once daily arm had a lower EQ-5D index worsening at 3 weeks (0.01 vs. –0.02). Increase in acute esophagitis score (1.06 vs. 2.89; p <.001) and difficulty swallowing (0.39 vs. 1.14) were greater in the twice daily arm at week 3. A total of 74.5% of patients on the once daily arm felt that treatment was convenient, compared to 67% of patients in the twice daily arm (p =.03). Conclusions: The once daily arm had better quality-of-life scores earlier during treatment and was perceived to be more convenient.

Original languageEnglish
Article numbere35663
JournalCancer
Volume131
Issue number1
DOIs
StatePublished - Jan 1 2025

Keywords

  • concurrent chemotherapy and radiation
  • limited stage small cell lung cancer
  • quality of life

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