Quality of life among patients post-myocardial infarction at baseline in the Survival and Ventricular Enlargement (SAVE) trial

L. Gorkin, M. J. Follick, E. Geltman, P. Hamm, J. S. Sollano, S. Sylvia, K. Jacobson, M. J. Jacobson, B. S. Cochrane, B. Sussex, M. Klein, G. Gaudette, D. Goldman, D. Carrol, R. Holcombe, D. K. Abern

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23 Scopus citations

Abstract

A quality of life ancillary study was incorporated into the Survival and Ventricular Enlargement (SAVE) trial of captopril versus placebo among patients who survived an acute myocardial infarction with compromised ventricular functioning, but no overt heart failure. Assessments included patient symptoms, health perceptions, emotional, cognitive, social and sexual levels of functloning, as well as potential covariates, such as life events and social support. The purpose of this study was to evaluate the psychometric properties of the quality of life measures in the SAVE at baseline, and provide a pre-randomization profile of the SAVE patients. One hundred and eighty-four patients participated in this aspect of the trial. Reliability alpha coefficlents were adequate or better for all questionnaires, except for life events and sexual activities. Consistent with prior studies, the quality of life parameters were uncorrelated with ventricular ejection fraction. Despite experiencing a recent myocardial infarction with compromised ventricular functioning, patients at baseline generally nelther appeared depressed nor focused on symptoms. The baseline findings support the inclusion of the quality of life ancillary study in the overall SAVE trial because of the independent contribution likely to be achieved in terms of evaluating both disease progression and treatment efficacy.

Original languageEnglish
Pages (from-to)111-119
Number of pages9
JournalQuality of Life Research
Volume3
Issue number2
DOIs
StatePublished - Apr 1994

Keywords

  • Left ventricular dysfunction
  • myocardial infarction
  • psychometrics
  • quality of life

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