Quality of life after management of advanced osteoradionecrosis of the mandible

A. S. Jacobson, J. Zevallos, M. Smith, C. L. Lazarus, H. Husaini, D. Okay, D. Buchbinder, M. Persky, M. L. Urken

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Osteoradionecrosis (ORN) of the mandible is a severe complication of radiation therapy for head and neck cancer. In this case series, the authors analyzed their treatment and quality of life outcomes over the past 6 years. A retrospective chart review of 42 patients treated surgically for advanced ORN was conducted. A telephone survey was conducted and quality of life (QOL) questionnaires were completed in a subset of patients. 30 patients responded to the telephone survey assessing QOL for speech, swallowing and overall functioning correlated with oral nutrition and performance status. Surgery for ORN can result in an improved QOL. Functional outcomes of oral intake, speech intelligibility, and eating in public correlated with patient rated QOL measures. A lack of improvement in QOL, despite the restoration of an intact mandible, relates to the persistent effects of chemoradiotherapy.

Original languageEnglish
Pages (from-to)1121-1128
Number of pages8
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number9
StatePublished - Sep 1 2013


  • functional outcomes
  • mandible reconstruction
  • osteoradionecrosis
  • quality of life
  • radiation therapy


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