TY - JOUR
T1 - Quality of life after high-dose-rate brachytherapy monotherapy for prostate cancer
AU - Contreras, Jessika A.
AU - Wilder, Richard B.
AU - Mellon, Eric A.
AU - Strom, Tobin J.
AU - Fernandez, Daniel C.
AU - Biagioli, Matthew C.
PY - 2015
Y1 - 2015
N2 - Purpose: There is little information in the literature on health-related quality of life (HRQOL) changes due to high-dose-rate (HDR) brachytherapy monotherapy for prostate cancer. Materials and Methods: We conducted a prospective study of HRQOL changes due to HDR brachytherapy monotherapy for low risk or favorable intermediate risk prostate cancer. Sixty-four of 84 (76%) patients who were treated between February 2011 and April 2013 completed 50 questions comprising the Expanded Prostate Cancer Index Composite (EPIC) before treatment and 6 and/or 12 months after treatment. Results: Six months after treatment, there was a significant decrease (p<0.05) in EPIC urinary, bowel, and sexual scores, including urinary overall, urinary function, urinary bother, urinary irritative, bowel overall, bowel bother, sexual overall, and sexual bother scores. By one year after treatment, EPIC urinary, bowel, and sexual scores had increased and only the bowel overall and bowel bother scores remained significantly below baseline values. Conclusions: HDR brachytherapy monotherapy is well-tolerated in patients with low and favorable intermediate risk prostate cancer. EPIC urinary and sexual domain scores returned to close to baseline 12 months after HDR brachytherapy.
AB - Purpose: There is little information in the literature on health-related quality of life (HRQOL) changes due to high-dose-rate (HDR) brachytherapy monotherapy for prostate cancer. Materials and Methods: We conducted a prospective study of HRQOL changes due to HDR brachytherapy monotherapy for low risk or favorable intermediate risk prostate cancer. Sixty-four of 84 (76%) patients who were treated between February 2011 and April 2013 completed 50 questions comprising the Expanded Prostate Cancer Index Composite (EPIC) before treatment and 6 and/or 12 months after treatment. Results: Six months after treatment, there was a significant decrease (p<0.05) in EPIC urinary, bowel, and sexual scores, including urinary overall, urinary function, urinary bother, urinary irritative, bowel overall, bowel bother, sexual overall, and sexual bother scores. By one year after treatment, EPIC urinary, bowel, and sexual scores had increased and only the bowel overall and bowel bother scores remained significantly below baseline values. Conclusions: HDR brachytherapy monotherapy is well-tolerated in patients with low and favorable intermediate risk prostate cancer. EPIC urinary and sexual domain scores returned to close to baseline 12 months after HDR brachytherapy.
KW - Brachytherapy
KW - Prostatic neoplasms
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=84929336282&partnerID=8YFLogxK
U2 - 10.1590/S1677-5538.IBJU.2015.01.07
DO - 10.1590/S1677-5538.IBJU.2015.01.07
M3 - Article
C2 - 25928509
AN - SCOPUS:84929336282
SN - 1677-5538
VL - 41
SP - 40
EP - 45
JO - International Braz J Urol
JF - International Braz J Urol
IS - 1
ER -