TY - JOUR
T1 - Quality Control in the ER
T2 - Misfolded Prohormones Get a Checkup
AU - Sprunger, Macy L.
AU - Jackrel, Meredith E.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/8/8
Y1 - 2019/8/8
N2 - In Mutant INS-gene-induced Diabetes of Youth (MIDY) syndrome, mutant proinsulin aggregates interfere with the folding of wild-type proinsulin in the endoplasmic reticulum, ultimately decreasing insulin secretion. In this issue of Molecular Cell, Cunningham et al. (2019) identify two mechanisms by which prohormone aggregation is prevented and cleared.
AB - In Mutant INS-gene-induced Diabetes of Youth (MIDY) syndrome, mutant proinsulin aggregates interfere with the folding of wild-type proinsulin in the endoplasmic reticulum, ultimately decreasing insulin secretion. In this issue of Molecular Cell, Cunningham et al. (2019) identify two mechanisms by which prohormone aggregation is prevented and cleared.
UR - http://www.scopus.com/inward/record.url?scp=85069678663&partnerID=8YFLogxK
U2 - 10.1016/j.molcel.2019.07.020
DO - 10.1016/j.molcel.2019.07.020
M3 - Short survey
C2 - 31398319
AN - SCOPUS:85069678663
SN - 1097-2765
VL - 75
SP - 415
EP - 416
JO - Molecular cell
JF - Molecular cell
IS - 3
ER -