Quality Control in the ER: Misfolded Prohormones Get a Checkup

Macy L. Sprunger, Meredith E. Jackrel

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


In Mutant INS-gene-induced Diabetes of Youth (MIDY) syndrome, mutant proinsulin aggregates interfere with the folding of wild-type proinsulin in the endoplasmic reticulum, ultimately decreasing insulin secretion. In this issue of Molecular Cell, Cunningham et al. (2019) identify two mechanisms by which prohormone aggregation is prevented and cleared.

Original languageEnglish
Pages (from-to)415-416
Number of pages2
JournalMolecular cell
Issue number3
StatePublished - Aug 8 2019


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