TY - JOUR
T1 - QT dynamicity
T2 - A prognostic factor for sudden cardiac death in chronic heart failure
AU - Pathak, Atul
AU - Curnier, Daniel
AU - Fourcade, Joëlle
AU - Roncalli, Jérôme
AU - Stein, Phyllis K.
AU - Hermant, Patricia
AU - Bousquet, Marc
AU - Massabuau, Pierre
AU - Sénard, Jean Michel
AU - Montastruc, Jean Louis
AU - Galinier, Michel
N1 - Funding Information:
This work was supported by SDIO/T/IS and managed by Los Alamos National Laboratory
PY - 2005/3/2
Y1 - 2005/3/2
N2 - Introduction: The aim of this study was to determine whether impaired adaptation of the QT interval to changes in heart rate predicts sudden death in patients with chronic heart failure (CHF). Methods: We prospectively included 175 CHF patients in sinus rhythm. QT dynamicity was evaluated by analyzing 24-h Holter recordings. The linear regression slope of QT interval measured to the apex and to the end of T wave plotted against RR intervals was calculated using a dedicated Holter algorithm. Results: Mean follow-up was 29.9±17.9 months. There were 48 deaths, of which 21 were sudden. The actuarial 3-year mortality rates were 38.4% for overall mortality and 14.1% for sudden death. Of all the parameters, an increased QTe/RR slope (>0.28) was the strongest independent predictor of sudden death (relative risk 3.47, 95% confidence interval 1.43-8.40, p=0.006). Conclusion: Increased 24-h QTe dynamicity is independently predictive of sudden death among patients with heart failure. This simple parameter may help to stratify risk and select patients who may benefit from antiarrhythmic prophylaxis.
AB - Introduction: The aim of this study was to determine whether impaired adaptation of the QT interval to changes in heart rate predicts sudden death in patients with chronic heart failure (CHF). Methods: We prospectively included 175 CHF patients in sinus rhythm. QT dynamicity was evaluated by analyzing 24-h Holter recordings. The linear regression slope of QT interval measured to the apex and to the end of T wave plotted against RR intervals was calculated using a dedicated Holter algorithm. Results: Mean follow-up was 29.9±17.9 months. There were 48 deaths, of which 21 were sudden. The actuarial 3-year mortality rates were 38.4% for overall mortality and 14.1% for sudden death. Of all the parameters, an increased QTe/RR slope (>0.28) was the strongest independent predictor of sudden death (relative risk 3.47, 95% confidence interval 1.43-8.40, p=0.006). Conclusion: Increased 24-h QTe dynamicity is independently predictive of sudden death among patients with heart failure. This simple parameter may help to stratify risk and select patients who may benefit from antiarrhythmic prophylaxis.
UR - http://www.scopus.com/inward/record.url?scp=20844450989&partnerID=8YFLogxK
U2 - 10.1016/j.ejheart.2004.10.016
DO - 10.1016/j.ejheart.2004.10.016
M3 - Article
C2 - 15701477
AN - SCOPUS:20844450989
VL - 7
SP - 269
EP - 275
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 2
ER -