Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1β-converting enzyme inhibitor

R. E. Dolle; C. V.C. Prasad; C. P. Prouty; J. M. Salvino; M. M.A. Awad; S. J. Schmidt; D. Hoyer; T. M. Ross; T. L. Graybill; G. J. Speier; J. Uhl; B. E. Miller; C. T. Helaszek; M. A. Ator

doi:10.1021/jm9701637

Pyridazinodiazepines as a high-affinity, P₂-P₃ peptidomimetic class of interleukin-1β-converting enzyme inhibitor

R. E. Dolle, C. V.C. Prasad, C. P. Prouty, J. M. Salvino, M. M.A. Awad, S. J. Schmidt, D. Hoyer, T. M. Ross, T. L. Graybill, G. J. Speier, J. Uhl, B. E. Miller, C. T. Helaszek, M. A. Ator

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Original language	English
Pages (from-to)	1941-1946
Number of pages	6
Journal	Journal of Medicinal Chemistry
Volume	40
Issue number	13
DOIs	https://doi.org/10.1021/jm9701637
State	Published - 1997

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Dolle, R. E., Prasad, C. V. C., Prouty, C. P., Salvino, J. M., Awad, M. M. A., Schmidt, S. J., Hoyer, D., Ross, T. M., Graybill, T. L., Speier, G. J., Uhl, J., Miller, B. E., Helaszek, C. T., & Ator, M. A. (1997). Pyridazinodiazepines as a high-affinity, P₂-P₃ peptidomimetic class of interleukin-1β-converting enzyme inhibitor. Journal of Medicinal Chemistry, 40(13), 1941-1946. https://doi.org/10.1021/jm9701637

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title = "Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1β-converting enzyme inhibitor",

author = "Dolle, {R. E.} and Prasad, {C. V.C.} and Prouty, {C. P.} and Salvino, {J. M.} and Awad, {M. M.A.} and Schmidt, {S. J.} and D. Hoyer and Ross, {T. M.} and Graybill, {T. L.} and Speier, {G. J.} and J. Uhl and Miller, {B. E.} and Helaszek, {C. T.} and Ator, {M. A.}",

note = "Funding Information: Acknowledgements The authors thank Dr. Masafumi Goto of Kajima Technical Research Institute for his critical reading of the manuscript. The authors also thank Miss Ikuko Sakamoto for her analytical support in the experiment. This work was supported by New Energy and Industrial Technology Development Organization (NEDO).",

year = "1997",

doi = "10.1021/jm9701637",

language = "English",

volume = "40",

pages = "1941--1946",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

number = "13",

}

Dolle, RE, Prasad, CVC, Prouty, CP, Salvino, JM, Awad, MMA, Schmidt, SJ, Hoyer, D, Ross, TM, Graybill, TL, Speier, GJ, Uhl, J, Miller, BE, Helaszek, CT & Ator, MA 1997, 'Pyridazinodiazepines as a high-affinity, P₂-P₃ peptidomimetic class of interleukin-1β-converting enzyme inhibitor', Journal of Medicinal Chemistry, vol. 40, no. 13, pp. 1941-1946. https://doi.org/10.1021/jm9701637

TY - JOUR

T1 - Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1β-converting enzyme inhibitor

AU - Dolle, R. E.

AU - Prasad, C. V.C.

AU - Prouty, C. P.

AU - Salvino, J. M.

AU - Awad, M. M.A.

AU - Schmidt, S. J.

AU - Hoyer, D.

AU - Ross, T. M.

AU - Graybill, T. L.

AU - Speier, G. J.

AU - Uhl, J.

AU - Miller, B. E.

AU - Helaszek, C. T.

AU - Ator, M. A.

N1 - Funding Information: Acknowledgements The authors thank Dr. Masafumi Goto of Kajima Technical Research Institute for his critical reading of the manuscript. The authors also thank Miss Ikuko Sakamoto for her analytical support in the experiment. This work was supported by New Energy and Industrial Technology Development Organization (NEDO).

PY - 1997

Y1 - 1997

UR - http://www.scopus.com/inward/record.url?scp=17144451277&partnerID=8YFLogxK

U2 - 10.1021/jm9701637

DO - 10.1021/jm9701637

M3 - Article

C2 - 9207934

AN - SCOPUS:17144451277

SN - 0022-2623

VL - 40

SP - 1941

EP - 1946

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 13

ER -

Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1β-converting enzyme inhibitor

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Pyridazinodiazepines as a high-affinity, P₂-P₃ peptidomimetic class of interleukin-1β-converting enzyme inhibitor