Pyrazole scaffold synthesis, functionalization, and applications in alzheimer’s disease and parkinson’s disease treatment (2011-2020)

Xuefei Li, Yanbo Yu, Zhude Tu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The remarkable prevalence of pyrazole scaffolds in a versatile array of bioactive molecules ranging from apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to bixafen, a pyrazole-carboxamide fungicide used to control diseases of rapeseed and cereal plants, has encouraged both medicinal and organic chemists to explore new methods in developing pyrazolecontaining compounds for different applications. Although numerous synthetic strategies have been developed in the last 10 years, there has not been a comprehensive overview of synthesis and the implication of recent advances for treating neurodegenerative disease. This review first presents the advances in pyrazole scaffold synthesis and their functionalization that have been published during the last decade (2011-2020). We then narrow the focus to the application of these strategies in the development of therapeutics for neurodegenerative diseases, particularly for Alzheimer’s disease (AD) and Parkinson’s disease (PD).

Original languageEnglish
Article number1202
JournalMolecules
Volume26
Issue number5
DOIs
StatePublished - Mar 1 2021

Keywords

  • Alzheimer’s disease
  • Antagonist
  • Biological activity
  • Functionalization
  • Heterocyclic
  • Inhibitor
  • Neurodegeneration
  • Parkinson’s disease
  • Pyrazole
  • Synthesis

Fingerprint

Dive into the research topics of 'Pyrazole scaffold synthesis, functionalization, and applications in alzheimer’s disease and parkinson’s disease treatment (2011-2020)'. Together they form a unique fingerprint.

Cite this