Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study.

J. D. Kaplan; E. P. Trulock; D. J. Anderson; D. P. Schuster

doi:10.1164/ajrccm/145.6.1495

Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study.

J. D. Kaplan
, E. P. Trulock
, D. J. Anderson
, D. P. Schuster

Division of Pulmonary & Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We evaluated pulmonary vascular permeability with positron emission tomography (PET) in 16 patients with interstitial lung disease (ILD) by measuring the pulmonary transcapillary escape rate (PTCER) for transferrin labeled with gallium-68. In patients with active ILD, defined by lung biopsy or clinical criteria, mean PTCER was significantly greater than in normal subjects (118 +/- 46 versus 21 +/- 11 x 10(-4) min-1, respectively, p less than 0.05). Mean PTCER in patients with inactive ILD, in contrast, was not different from that in normal subjects (32 +/- 10 x 10(-4) min-1, p = NS). Thus, these data suggest that PET measurements of PTCER might serve as an index of disease activity in patients with ILD.

Original language	English
Pages (from-to)	1495-1498
Number of pages	4
Journal	The American review of respiratory disease
Volume	145
Issue number	6
DOIs	https://doi.org/10.1164/ajrccm/145.6.1495
State	Published - Jun 1992

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title = "Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study.",

abstract = "We evaluated pulmonary vascular permeability with positron emission tomography (PET) in 16 patients with interstitial lung disease (ILD) by measuring the pulmonary transcapillary escape rate (PTCER) for transferrin labeled with gallium-68. In patients with active ILD, defined by lung biopsy or clinical criteria, mean PTCER was significantly greater than in normal subjects (118 +/- 46 versus 21 +/- 11 x 10(-4) min-1, respectively, p less than 0.05). Mean PTCER in patients with inactive ILD, in contrast, was not different from that in normal subjects (32 +/- 10 x 10(-4) min-1, p = NS). Thus, these data suggest that PET measurements of PTCER might serve as an index of disease activity in patients with ILD.",

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AU - Schuster, D. P.

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AB - We evaluated pulmonary vascular permeability with positron emission tomography (PET) in 16 patients with interstitial lung disease (ILD) by measuring the pulmonary transcapillary escape rate (PTCER) for transferrin labeled with gallium-68. In patients with active ILD, defined by lung biopsy or clinical criteria, mean PTCER was significantly greater than in normal subjects (118 +/- 46 versus 21 +/- 11 x 10(-4) min-1, respectively, p less than 0.05). Mean PTCER in patients with inactive ILD, in contrast, was not different from that in normal subjects (32 +/- 10 x 10(-4) min-1, p = NS). Thus, these data suggest that PET measurements of PTCER might serve as an index of disease activity in patients with ILD.

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Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study.

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