Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study.

J. D. Kaplan, E. P. Trulock, D. J. Anderson, D. P. Schuster

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We evaluated pulmonary vascular permeability with positron emission tomography (PET) in 16 patients with interstitial lung disease (ILD) by measuring the pulmonary transcapillary escape rate (PTCER) for transferrin labeled with gallium-68. In patients with active ILD, defined by lung biopsy or clinical criteria, mean PTCER was significantly greater than in normal subjects (118 +/- 46 versus 21 +/- 11 x 10(-4) min-1, respectively, p less than 0.05). Mean PTCER in patients with inactive ILD, in contrast, was not different from that in normal subjects (32 +/- 10 x 10(-4) min-1, p = NS). Thus, these data suggest that PET measurements of PTCER might serve as an index of disease activity in patients with ILD.

Original languageEnglish
Pages (from-to)1495-1498
Number of pages4
JournalThe American review of respiratory disease
Volume145
Issue number6
DOIs
StatePublished - Jun 1992

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