TY - JOUR
T1 - Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study.
AU - Kaplan, J. D.
AU - Trulock, E. P.
AU - Anderson, D. J.
AU - Schuster, D. P.
PY - 1992/6
Y1 - 1992/6
N2 - We evaluated pulmonary vascular permeability with positron emission tomography (PET) in 16 patients with interstitial lung disease (ILD) by measuring the pulmonary transcapillary escape rate (PTCER) for transferrin labeled with gallium-68. In patients with active ILD, defined by lung biopsy or clinical criteria, mean PTCER was significantly greater than in normal subjects (118 +/- 46 versus 21 +/- 11 x 10(-4) min-1, respectively, p less than 0.05). Mean PTCER in patients with inactive ILD, in contrast, was not different from that in normal subjects (32 +/- 10 x 10(-4) min-1, p = NS). Thus, these data suggest that PET measurements of PTCER might serve as an index of disease activity in patients with ILD.
AB - We evaluated pulmonary vascular permeability with positron emission tomography (PET) in 16 patients with interstitial lung disease (ILD) by measuring the pulmonary transcapillary escape rate (PTCER) for transferrin labeled with gallium-68. In patients with active ILD, defined by lung biopsy or clinical criteria, mean PTCER was significantly greater than in normal subjects (118 +/- 46 versus 21 +/- 11 x 10(-4) min-1, respectively, p less than 0.05). Mean PTCER in patients with inactive ILD, in contrast, was not different from that in normal subjects (32 +/- 10 x 10(-4) min-1, p = NS). Thus, these data suggest that PET measurements of PTCER might serve as an index of disease activity in patients with ILD.
UR - http://www.scopus.com/inward/record.url?scp=0026878301&partnerID=8YFLogxK
U2 - 10.1164/ajrccm/145.6.1495
DO - 10.1164/ajrccm/145.6.1495
M3 - Article
C2 - 1596025
AN - SCOPUS:0026878301
SN - 0003-0805
VL - 145
SP - 1495
EP - 1498
JO - The American review of respiratory disease
JF - The American review of respiratory disease
IS - 6
ER -