Pulmonary pleomorphic carcinoma after malignant lymphoma remission: A case report

Tsuyoshi Takahashi, Masako Kurihara, Hiroshi Nogimura, Ryo Kobayashi

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A 78-year-old woman diagnosed with diffuse large B-cell lymphoma in the left supra-pharynx and left supraclavicular lymph nodes showed complete remission after undergoing radiation therapy and chemotherapy in September 2006. In September 2008, during a routine follow-up evaluation for the malignant lymphoma, elevated levels of soluble interleukin-2 receptor were detected in the serum; moreover, computed tomography revealed a nodule in the right middle lobe and mediastinal lymphadenopathy. Recurrence of the malignant lymphoma was suspected, and the patient underwent a chemotherapy regimen of rituximab combined with pirarubicin, cyclophosphamide, vincristine, and prednisolone. However, her general condition deteriorated and she died. The postmortem autopsy revealed a pulmonary pleomorphic carcinoma with metastases to the mediastinal lymph nodes. However, there was no evidence of malignant lymphoma recurrence. We encountered a case of pulmonary pleomorphic carcinoma that occurred after the remission of a malignant lymphoma.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalJapanese Journal of Chest Diseases
Issue number2
StatePublished - Feb 1 2015


  • Chemotherapy
  • Malignant lymphoma
  • Pleomorphic carcinoma of the lung


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