Pulmonary hyalinizing granuloma associated with Aspergillus infection

J. Keith Pinckard, Daniel B. Rosenbluth, Kishor Patel, Louis P. Dehner, John D. Pfeifer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A 38-year-old immunocompetent man with occupational exposure to Aspergillus presented with dyspnea, pleuritic chest pain, and hemoptysis. Chest roentgenograms and computed tomography scans demonstrated multiple pulmonary nodules bilaterally. An initial set of bronchial washing cultures grew Aspergillus fumigatus, serologic testing showed an elevated anti-Aspergillus titer, and immunodiffusion testing was positive for antibody against A. fumigatus and A. niger. There was no microbiologic or serologic evidence of infection by other pathogens, and no clinical or laboratory evidence of autoimmune disease. An open lung biopsy was diagnostic of pulmonary hyalinizing granuloma. This novel association with Aspergillus infection not only expands the spectrum of pathogens linked to pulmonary hyalinizing granuloma but also documents a new pattern of lung disease that can be caused by Aspergillus.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalInternational Journal of Surgical Pathology
Issue number1
StatePublished - Jan 2003


  • Aspergillus
  • Lung
  • Pulmonary hyalinizing granuloma


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