TY - JOUR
T1 - Pulmonary blood flow distribution during partial liquid ventilation
AU - Doctor, Allan
AU - Ibla, Juan C.
AU - Grenier, Barry M.
AU - Zurakowski, David
AU - Ferretti, Michelle L.
AU - Thompson, John E.
AU - Lillehei, Craig W.
AU - Arnold, John H.
PY - 1998/5
Y1 - 1998/5
N2 - Regional pulmonary blood flow was investigated with radiolabeled microspheres in four supine lambs during the transition from conventional mechanical ventilation (CMV) to partial liquid ventilation (PLV) and with incremental dosing of perfluorocarbon liquid to a cumulative dose of 30 ml/kg. Four lambs supported with CMV served as controls. Formalin-fixed, air- dried lungs were sectioned according to a grid; activity was quantitated with a multichannel scintillation counter, corrected for weight, and normalized to mean flow. During CMV, flow in apical and hilar regions favored dependent lung (P < 0.001), with no gradient across transverse planes from apex to diaphragm. During PLV the gradient within transverse planes found during CMV reversed, most notably in the hilar region, favoring nondependent lung (P = 0.03). Also during PLV, flow was profoundly reduced near the diaphragm (P < 0.001), and across transverse planes from apex to diaphragm a dose-augmented flow gradient developed favoring apical lung (P < 0.01). We conclude that regional flow patterns during PLV partially reverse those noted during CMV and vary dramatically within the lung from apex to diaphragm.
AB - Regional pulmonary blood flow was investigated with radiolabeled microspheres in four supine lambs during the transition from conventional mechanical ventilation (CMV) to partial liquid ventilation (PLV) and with incremental dosing of perfluorocarbon liquid to a cumulative dose of 30 ml/kg. Four lambs supported with CMV served as controls. Formalin-fixed, air- dried lungs were sectioned according to a grid; activity was quantitated with a multichannel scintillation counter, corrected for weight, and normalized to mean flow. During CMV, flow in apical and hilar regions favored dependent lung (P < 0.001), with no gradient across transverse planes from apex to diaphragm. During PLV the gradient within transverse planes found during CMV reversed, most notably in the hilar region, favoring nondependent lung (P = 0.03). Also during PLV, flow was profoundly reduced near the diaphragm (P < 0.001), and across transverse planes from apex to diaphragm a dose-augmented flow gradient developed favoring apical lung (P < 0.01). We conclude that regional flow patterns during PLV partially reverse those noted during CMV and vary dramatically within the lung from apex to diaphragm.
KW - Liquid ventilation
KW - Mechanical ventilation
KW - Partial liquid ventilation
KW - Perflubron
KW - Perfluorochemical
KW - Pulmonary circulation
KW - Pulmonary vascular resistance
UR - http://www.scopus.com/inward/record.url?scp=0031967901&partnerID=8YFLogxK
U2 - 10.1152/jappl.1998.84.5.1540
DO - 10.1152/jappl.1998.84.5.1540
M3 - Article
C2 - 9572797
AN - SCOPUS:0031967901
SN - 0161-7567
VL - 84
SP - 1540
EP - 1550
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 5
ER -