Pulmonary alveolar proteinosis: An uncommon cause of chronic neonatal respiratory distress

M. Coleman, L. P. Dehner, R. K. Sibley, B. A. Burke, P. R. L'Heureux, T. R. Thompson

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

A full-term newborn infant had the onset of respiratory distress immediately after birth. She required supplemental oxygen from birth, and had pulmonary alveolar proteinosis (PAP) documented by open lung biopsies at 6 and 12 weeks of age. Light and electron microscopy showed dense, PAS-positive granular, homogeneous material within the alveolar spaces, diagnostic of PAP. No Pneumocystis carinii organisms were demonstrated on silver staining, and bacterial and viral cultures were negative. The infant died of progressive respiratory insufficiency at 1 yr of age. Pulmonary alveolar proteinosis should be considered a rare cause of chronic respiratory distress in the newborn infant.

Original languageEnglish
Pages (from-to)583-586
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume121
Issue number3
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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