Keyphrases
Leishmania Major
100%
Protozoan Parasites
100%
Reductase
100%
PTR1
100%
Pteridines
100%
Methotrexate Resistance
100%
Methotrexate
30%
Dihydrobiopterin
30%
Pteridine Reductase 1
30%
Leishmania
20%
Biopterin
20%
Multi-copy
20%
Trypanosomatids
20%
Reductase Activity
20%
Eukaryotes
10%
Vertebrates
10%
Transfectant
10%
Possible Mechanisms
10%
Large Families
10%
Oxidoreductase
10%
Folate
10%
Pterin
10%
Nicotinamide Adenine Dinucleotide Phosphate (NADPH)
10%
Biochemical Properties
10%
Metabolic Role
10%
Auxotroph
10%
Diverse Roles
10%
Dihydrofolate
10%
Diverse Substrates
10%
Genetic Properties
10%
Engineered Escherichia Coli
10%
Human Parasite
10%
Tetrahydrobiopterin
10%
Homologous Gene Targeting
10%
Quinonoid
10%
Rational Chemotherapy
10%
Biochemistry, Genetics and Molecular Biology
Oxidoreductase
100%
Reductase
100%
Protozoon
100%
Leishmania Major
100%
Methotrexate
100%
Enzyme
33%
Leishmania
33%
Trypanosomatidae
33%
Sapropterin
33%
Genetics
16%
Eukaryote
16%
Gene Targeting
16%
Escherichia coli
16%
Folic Acid
16%
Auxotrophy
16%
Biopterin
16%