Abstract

Identification of monogenic causes of immune dysregulation provides insight into human immune response and signaling pathways associated with autoimmunity. Here, Jeanpierre et al. (https://doi.org/10.1084/jem.20232337) identify new germline variants in the gene encoding PTPN2 associated with loss of regulatory function, enhanced JAK/STAT signaling, and earlyonset autoimmunity.

Original languageEnglish
Article numbere20240980
JournalJournal of Experimental Medicine
Volume221
Issue number9
DOIs
StatePublished - Sep 2 2024

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