Psychometric evaluation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (Fact/GOG-Ntx) questionnaire for patients receiving systemic chemotherapy

Elizabeth A. Calhoun, E. E. Welshman, C. H. Chang, J. R. Lurain, D. A. Fishman, T. L. Hunt, D. Cella

Research output: Contribution to journalArticlepeer-review

216 Scopus citations

Abstract

The purpose of this study was to validate the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire. The FACT/GOG-Ntx is the FACT-G plus an eleven-item subscale (Ntx subscale) that evaluates symptoms and concerns associated specifically with chemotherapy-induced neuropathy. Two groups of women with ovarian cancer completed the FACT/GOG-Ntx: One group with known neurotoxicities and one group of chemotherapy-naive women newly diagnosed with ovarian cancer. Levels of patient neuropathy, severity of toxicity, and patient quality of life from diagnosis of ovarian cancer to 12 months post-diagnosis were assessed. The Ntx subscale significantly differentiated the two groups at baseline and 3- and 6-month follow-ups, demonstrating significantly fewer problems among chemotherapy-naive patients than among patients with known neuropathy. The FACT/GOG-Ntx is a reliable and valid instrument for assessing the impact of neuropathy on health-related quality of life. The Ntx subscale demonstrated sensitivity to meaningful clinical distinctions and change over time.

Original languageEnglish
Pages (from-to)741-748
Number of pages8
JournalInternational Journal of Gynecological Cancer
Volume13
Issue number6
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

Keywords

  • Neurotoxicity
  • Patient-reported outcomes
  • Peripheral neuropathy
  • Quality of life

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