TY - JOUR
T1 - Psychiatric comorbidity and progression in drug use in adult male twins
T2 - Implications for the design of genetic association studies
AU - Todorov, Alexandre A.
AU - Lynskey, Michael T.
AU - Grant, Julia D.
AU - Scherrer, Jeffrey F.
AU - Todd, Richard D.
AU - Bucholz, Kathleen Keenan
N1 - Funding Information:
This study was supported in part by grants DA-14363, DA-14632, DA-18660, AA-13640 and AA-11998.
PY - 2006/6
Y1 - 2006/6
N2 - Psychiatric comorbidity with drug dependence has been widely documented. In the present study, we reanalyze DSM-III-R diagnostic data on middle-aged male twin pairs from the VETR study using latent class methods. We identify four subtypes based on 15 diagnostic categories. We then show that these subtypes are strongly associated with differential rates of transitions in drug use histories, with increased risks in relatives for depression, alcohol, drug and ASPD, as well as with a variety of non-normative and deviant behaviors in youth and in adulthood. We use the result of these analyses to show how the use of a particular drug disorder phenotype for selecting cases could impact final sample composition.
AB - Psychiatric comorbidity with drug dependence has been widely documented. In the present study, we reanalyze DSM-III-R diagnostic data on middle-aged male twin pairs from the VETR study using latent class methods. We identify four subtypes based on 15 diagnostic categories. We then show that these subtypes are strongly associated with differential rates of transitions in drug use histories, with increased risks in relatives for depression, alcohol, drug and ASPD, as well as with a variety of non-normative and deviant behaviors in youth and in adulthood. We use the result of these analyses to show how the use of a particular drug disorder phenotype for selecting cases could impact final sample composition.
KW - Alcohol use disorder
KW - Genetic association study
KW - Psychiatric co-morbidity
KW - Substance use disorder
UR - http://www.scopus.com/inward/record.url?scp=33646839826&partnerID=8YFLogxK
U2 - 10.1016/j.addbeh.2006.03.046
DO - 10.1016/j.addbeh.2006.03.046
M3 - Article
C2 - 16713123
AN - SCOPUS:33646839826
SN - 0306-4603
VL - 31
SP - 948
EP - 961
JO - Addictive Behaviors
JF - Addictive Behaviors
IS - 6
ER -