Psychedelics reduce fear by targeting immune cells that modulate brain cells

Yun Chen; Marco Colonna

doi:10.1038/d41586-025-01133-9

Psychedelics reduce fear by targeting immune cells that modulate brain cells

Yun Chen
, Marco Colonna

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

Immune cells boost stress-linked fear responses by communicating with brain cells. One way that psychedelics lessen such fear is by modulating this interaction.

Original language	English
Pages (from-to)	1105-1108
Number of pages	4
Journal	Nature
Volume	641
Issue number	8065
DOIs	https://doi.org/10.1038/d41586-025-01133-9
State	Published - May 29 2025

Keywords

Immunology
Neuroscience

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10.1038/d41586-025-01133-9

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title = "Psychedelics reduce fear by targeting immune cells that modulate brain cells",

abstract = "Immune cells boost stress-linked fear responses by communicating with brain cells. One way that psychedelics lessen such fear is by modulating this interaction.",

keywords = "Immunology, Neuroscience",

author = "Yun Chen and Marco Colonna",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2025.",

year = "2025",

month = may,

day = "29",

doi = "10.1038/d41586-025-01133-9",

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AU - Chen, Yun

AU - Colonna, Marco

N1 - Publisher Copyright: © Springer Nature Limited 2025.

PY - 2025/5/29

Y1 - 2025/5/29

N2 - Immune cells boost stress-linked fear responses by communicating with brain cells. One way that psychedelics lessen such fear is by modulating this interaction.

AB - Immune cells boost stress-linked fear responses by communicating with brain cells. One way that psychedelics lessen such fear is by modulating this interaction.

KW - Immunology

KW - Neuroscience

UR - https://www.scopus.com/pages/publications/105003947034

U2 - 10.1038/d41586-025-01133-9

DO - 10.1038/d41586-025-01133-9

M3 - Comment/debate

C2 - 40269302

AN - SCOPUS:105003947034

SN - 0028-0836

VL - 641

SP - 1105

EP - 1108

JO - Nature

JF - Nature

IS - 8065

ER -

Psychedelics reduce fear by targeting immune cells that modulate brain cells

Abstract

Keywords

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