Pseudotumor of the Tracheal-Laryngeal Junction with Unusual Morphologic Features Caused by Rhodococcus equi Infection

Shreeram Akilesh, Sara Cross, Katherine Kimmelshue, Nigar Kirmani, Louis P. Dehner, Samir K. El-Mofty

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Infectious pseudotumors are unusual proliferations of histiocytes in response to certain microbial organisms. Occasionally this process may involve large airways, producing a mass lesion that may cause respiratory obstruction. Infectious pseudotumors can be confused with malignancy in their radiologic appearance and clinical presentation. We present a case of an aggressive endotracheal pseudotumor associated with Rhodococcus equi infection in a patient with advanced HIV disease. Microscopically, the lesion was composed of sheets of epithelioid histiocytes with large, strongly eosinophilic intra-cytoplasmic granules and features of malakoplakia. In this report, we review the literature of these unusual lesions and compare them to cases of conventional malakoplakia involving the large airways. We also explore the pathogenetic mechanisms that may contribute to the distinctive histologic appearance of Rhodococcus-associated pseudotumors.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalHead and Neck Pathology
Volume5
Issue number4
DOIs
StatePublished - Dec 2011

Keywords

  • Endobronchial mass lesion
  • Human immunodeficiency virus (HIV)
  • Infectious pseudotumor
  • Malakoplakia
  • Rhodococcus equi

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