Pseudoautologous blood stem cell transplantation for refractory chronic graft-versus-host disease

I. Pusic, S. Z. Pavletic, A. Kessinger, S. R. Tarantolo, M. R. Bishop

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A female patient with AML received an allogeneic BMT from her brother. She experienced two relapses managed with chemotherapy and donor leukocyte infusions. The patient subsequently developed extensive therapy-refractory chronic GVHD. Pseudoautologous blood stem cell transplantation was performed as a salvage treatment for chronic GVHD. Her blood stem cells were easily mobilized with cyclophosphamide and G-CSF. The conditioning regimen was well tolerated and consisted of 200 mg/kg cyclophosphamide and horse-derived antithymocyte globulin. A total of 4.03 × 106/kg CD34+ cells were infused and hematological recovery was rapid. Chronic GVHD improved with the ability to taper steroids. Nine months post transplantation the patient died from leukemia.

Original languageEnglish
Pages (from-to)709-710
Number of pages2
JournalBone Marrow Transplantation
Volume29
Issue number8
DOIs
StatePublished - 2002

Keywords

  • AML
  • Chronic graft-versus-host disease
  • Hematopoietic stem cell transplantation

Fingerprint

Dive into the research topics of 'Pseudoautologous blood stem cell transplantation for refractory chronic graft-versus-host disease'. Together they form a unique fingerprint.

Cite this