Pseudoautologous blood stem cell transplantation for refractory chronic graft-versus-host disease

I. Pusic; S. Z. Pavletic; A. Kessinger; S. R. Tarantolo; M. R. Bishop

doi:10.1038/sj.bmt.1703550

Pseudoautologous blood stem cell transplantation for refractory chronic graft-versus-host disease

I. Pusic, S. Z. Pavletic, A. Kessinger, S. R. Tarantolo, M. R. Bishop

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12 Scopus citations

Abstract

A female patient with AML received an allogeneic BMT from her brother. She experienced two relapses managed with chemotherapy and donor leukocyte infusions. The patient subsequently developed extensive therapy-refractory chronic GVHD. Pseudoautologous blood stem cell transplantation was performed as a salvage treatment for chronic GVHD. Her blood stem cells were easily mobilized with cyclophosphamide and G-CSF. The conditioning regimen was well tolerated and consisted of 200 mg/kg cyclophosphamide and horse-derived antithymocyte globulin. A total of 4.03 × 10⁶/kg CD34⁺ cells were infused and hematological recovery was rapid. Chronic GVHD improved with the ability to taper steroids. Nine months post transplantation the patient died from leukemia.

Original language	English
Pages (from-to)	709-710
Number of pages	2
Journal	Bone Marrow Transplantation
Volume	29
Issue number	8
DOIs	https://doi.org/10.1038/sj.bmt.1703550
State	Published - 2002

Keywords

AML
Chronic graft-versus-host disease
Hematopoietic stem cell transplantation

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abstract = "A female patient with AML received an allogeneic BMT from her brother. She experienced two relapses managed with chemotherapy and donor leukocyte infusions. The patient subsequently developed extensive therapy-refractory chronic GVHD. Pseudoautologous blood stem cell transplantation was performed as a salvage treatment for chronic GVHD. Her blood stem cells were easily mobilized with cyclophosphamide and G-CSF. The conditioning regimen was well tolerated and consisted of 200 mg/kg cyclophosphamide and horse-derived antithymocyte globulin. A total of 4.03 × 106/kg CD34+ cells were infused and hematological recovery was rapid. Chronic GVHD improved with the ability to taper steroids. Nine months post transplantation the patient died from leukemia.",

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AU - Kessinger, A.

AU - Tarantolo, S. R.

AU - Bishop, M. R.

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AB - A female patient with AML received an allogeneic BMT from her brother. She experienced two relapses managed with chemotherapy and donor leukocyte infusions. The patient subsequently developed extensive therapy-refractory chronic GVHD. Pseudoautologous blood stem cell transplantation was performed as a salvage treatment for chronic GVHD. Her blood stem cells were easily mobilized with cyclophosphamide and G-CSF. The conditioning regimen was well tolerated and consisted of 200 mg/kg cyclophosphamide and horse-derived antithymocyte globulin. A total of 4.03 × 106/kg CD34+ cells were infused and hematological recovery was rapid. Chronic GVHD improved with the ability to taper steroids. Nine months post transplantation the patient died from leukemia.

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Pseudoautologous blood stem cell transplantation for refractory chronic graft-versus-host disease

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