TY - JOUR
T1 - Provisional Tic Disorder is not so transient
AU - Kim, Soyoung
AU - Greene, Deanna J.
AU - Bihun, Emily C.
AU - Koller, Jonathan M.
AU - Hampton, Jacqueline M.
AU - Acevedo, Haley
AU - Reiersen, Angela M.
AU - Schlaggar, Bradley L.
AU - Black, Kevin J.
N1 - Funding Information:
An earlier version of this manuscript appeared on OSF Preprints. We thank Dr. Jimin Ding for advising on the statistical analysis and Matthew T. de la Paz for help with data organization. Some of these results were presented at the 2018 American Neuropsychiatric Association’s annual meeting. Research reported in this publication was supported by National Institutes of Health, awards K24 MH087913 to KJB; R21 NS091635 to BLS and KJB; K01 MH104592 to DJG; R01 MH104030 to KJB and BLS; the Washington University Institute of Clinical and Translational Sciences grants UL1 RR024992 and UL1 TR000448; the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University; and by a research grant from the Tourette Association of America to DJG. The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH or TAA.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Motor and vocal tics are common in childhood. The received wisdom among clinicians is that for most children the tics are temporary, disappearing within a few months. However, that common clinical teaching is based largely on biased and incomplete data. The present study was designed to prospectively assess outcome of children with what the current nomenclature calls Provisional Tic Disorder. We identified 43 children with recent onset tics (mean 3.3 months since tic onset) and re-examined 39 of them on the 12-month anniversary of their first tic. Tic symptoms improved on a group level at the 12-month follow-up, and only two children had more than minimal impairment due to tics. Remarkably, however, tics were present in all children at follow-up, although in several cases tics were apparent only when the child was observed remotely by video. Our results suggest that remission of Provisional Tic Disorder is the exception rather than the rule. We also identified several clinical features present at the first examination that predict one-year outcome; these include baseline tic severity, subsyndromal autism spectrum symptoms, and the presence of an anxiety disorder.
AB - Motor and vocal tics are common in childhood. The received wisdom among clinicians is that for most children the tics are temporary, disappearing within a few months. However, that common clinical teaching is based largely on biased and incomplete data. The present study was designed to prospectively assess outcome of children with what the current nomenclature calls Provisional Tic Disorder. We identified 43 children with recent onset tics (mean 3.3 months since tic onset) and re-examined 39 of them on the 12-month anniversary of their first tic. Tic symptoms improved on a group level at the 12-month follow-up, and only two children had more than minimal impairment due to tics. Remarkably, however, tics were present in all children at follow-up, although in several cases tics were apparent only when the child was observed remotely by video. Our results suggest that remission of Provisional Tic Disorder is the exception rather than the rule. We also identified several clinical features present at the first examination that predict one-year outcome; these include baseline tic severity, subsyndromal autism spectrum symptoms, and the presence of an anxiety disorder.
UR - http://www.scopus.com/inward/record.url?scp=85062617204&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-40133-4
DO - 10.1038/s41598-019-40133-4
M3 - Article
C2 - 30850688
AN - SCOPUS:85062617204
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 3951
ER -