Proton magnetic resonance imaging of the ocular lens

Hong Ming Cheng, Lung I. Yen, Patrick Barnett, Stefano Miglior, J. Chris Eagon, Gilberto González, Thomas J. Brady

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Several osmotic cataract models as well as human diabetic lenses were tested by nuclear magnetic resonance spectroscopy and imaging. Both longitudinal (T1) and transverse (T2) relaxation times increased with increase in lens hydration. Therefore proton magnetic resonance imaging (MRI) can be used to detect changes of the biophysical environment of water proton in the lens. T2-weighted imaging sequence (spin-echo) can be used to differentiate lenses with hydrational changes since they exhibit higher signal intensity (because of long T2) than normal lenses at the same TE (echo time). A greater contrast can be achieved with the inversion-recovery sequence, which, in addition to contribution from T2, also incorporates T1 and proton density terms. Proton MRI is potentially useful for the detection of pre-cataractous changes.

Original languageEnglish
Pages (from-to)875-882
Number of pages8
JournalExperimental eye research
Issue number6
StatePublished - Dec 1987


  • MRI
  • Proton NMR imaging
  • T1
  • T2
  • cataract
  • diabetes
  • hydration
  • lens
  • pulse sequence


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