Proteomic studies on the white matter of human brain

Stefano Pozzi Mucelli, Federico Odreman, Marlen Lujardo Gonzales, Ernestina Gerardi, Giorgio Stanta, Alessandro Vindigni

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Limited information on the protein expression profiles of the different components of mammalian brain is available to date. In the present study, proteomic analysis was performed on 32 white matter samples obtained from 8 different regions of brains of four post mortem cases. Proteins were separated by 2D gel electrophoresis and identified by mass spectrometry. Most of the protein spots (98%) are reproducibly present in all the samples analyzed. A total of 64 different proteins were identified and divided into seven functional groups. These include metabolic proteins (33%), structural proteins (9%), proteins involved in signal transduction (9%), blood proteins (8%), stress related proteins (23%), and proteins involved in the ubiquitin mediated proteolysis (6%). This protein database obtained from the white matter of human brain contributes to deepen our knowledge on the molecular mechanisms that control several pathologies affecting this key component of the brain.

Original languageEnglish
Pages (from-to)80-90
Number of pages11
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Issue number1
StatePublished - Mar 20 2006


  • 2D electrophoresis
  • Brain white matter
  • Human brain
  • Mass spectrometry
  • Proteomics


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