Proteomic characterization of novel histone post-translational modifications

Anna M. Arnaudo, Benjamin A. Garcia

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations

Abstract

Histone post-translational modifications (PTMs) have been linked to a variety of biological processes and disease states, thus making their characterization a critical field of study. In the last 5 years, a number of novel sites and types of modifications have been discovered, greatly expanding the histone code. Mass spectrometric methods are essential for finding and validating histone PTMs. Additionally, novel proteomic, genomic and chemical biology tools have been developed to probe PTM function. In this snapshot review, proteomic tools for PTM identification and characterization will be discussed and an overview of PTMs found in the last 5 years will be provided.

Original languageEnglish
Article number24
JournalEpigenetics and Chromatin
Volume6
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Epigenetics
  • Histone post-translational modifications
  • Mass spectrometry
  • Proteomics

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