Abstract

The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets connecting genomic aberrations to cancer phenotypes. To facilitate pan-cancer investigations, we have generated harmonized genomic, transcriptomic, proteomic, and clinical data for >1000 tumors in 10 cohorts to create a cohesive and powerful dataset for scientific discovery. We outline efforts by the CPTAC pan-cancer working group in data harmonization, data dissemination, and computational resources for aiding biological discoveries. We also discuss challenges for multi-omics data integration and analysis, specifically the unique challenges of working with both nucleotide sequencing and mass spectrometry proteomics data.

Original languageEnglish
Pages (from-to)1397-1406
Number of pages10
JournalCancer Cell
Volume41
Issue number8
DOIs
StatePublished - Aug 14 2023

Keywords

  • CPTAC
  • data harmonization
  • multi-omics
  • open data
  • pan-cancer
  • proteogenomics

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