TY - JOUR
T1 - Protein Z and protein Z-dependent protease inhbitor. Determinants of level and risk of venous thrombosis
AU - Al-Shanqeeti, Ali
AU - van Hylckama Vlieg, Astrid
AU - Berntorp, Erik
AU - Rosendaal, Frits R.
AU - Broze, George J.
PY - 2005/3
Y1 - 2005/3
N2 - To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the over-all case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
AB - To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the over-all case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
KW - Clinical/epidemiological studies
KW - Coagulation inhibitors
KW - Thrombophilia
UR - http://www.scopus.com/inward/record.url?scp=15344345528&partnerID=8YFLogxK
U2 - 10.1160/TH04-11-0715
DO - 10.1160/TH04-11-0715
M3 - Article
C2 - 15735788
AN - SCOPUS:15344345528
SN - 0340-6245
VL - 93
SP - 411
EP - 413
JO - Thrombosis and haemostasis
JF - Thrombosis and haemostasis
IS - 3
ER -