Protein Z and protein Z-dependent protease inhbitor. Determinants of level and risk of venous thrombosis

Ali Al-Shanqeeti, Astrid van Hylckama Vlieg, Erik Berntorp, Frits R. Rosendaal, George J. Broze

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the over-all case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
JournalThrombosis and haemostasis
Volume93
Issue number3
DOIs
StatePublished - Mar 1 2005

Keywords

  • Clinical/epidemiological studies
  • Coagulation inhibitors
  • Thrombophilia

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    Al-Shanqeeti, A., van Hylckama Vlieg, A., Berntorp, E., Rosendaal, F. R., & Broze, G. J. (2005). Protein Z and protein Z-dependent protease inhbitor. Determinants of level and risk of venous thrombosis. Thrombosis and haemostasis, 93(3), 411-413. https://doi.org/10.1160/TH04-11-0715