Protein turnover in intestinal mucosal villus and crypt brush border membranes

Research output: Contribution to journalArticle

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Abstract

Relative turnover rates of intestinal brush border proteins have been studied by double labelled technique. Brush borders were isolated from cells at all levels along the villus, and from the crypts. Proteins with large molecular weight (>150,000) demonstrated more rapid turnover compared with other brush border proteins at all levels along the villus. This rapid turnover was not seen in crypt brush borders. These findings support the concept of protein turnover in intestinal brush borders, and demonstrate differences between the proteins in rapidly growing crypt cells and non growing villus cells.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume75
Issue number1
DOIs
StatePublished - Mar 7 1977

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