Protein transduction: Unrestricted delivery into all cells?

Steven R. Schwarze, Keith A. Hruska, Steven F. Dowdy

Research output: Contribution to journalReview articlepeer-review

506 Scopus citations

Abstract

Several proteins can traverse biological membranes through protein transduction. Small sections of these proteins (10-16 residues long) are responsible for this. Linking these domains covalently to compounds, peptides, antisense peptide nucleic acids or 40-nm iron beads, or as in-frame fusions with full-length proteins, lets them enter any cell type in a receptor- and transporter-independent fashion. Moreover, several of these fusions, introduced into mice, were delivered to all tissues, even crossing the blood-brain barrier. These domains thus might let us address new questions and even help in the treatment of human disease. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)290-295
Number of pages6
JournalTrends in Cell Biology
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2000

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