Abstract
In the three-dimensional structure of proteins, domains are stably folded structural units that retain molecular function independent of the rest of the larger protein. Here we review the basic building blocks of protein structure, provide an overview of molecular functions of protein domains for macromolecular interactions, ligand binding, and catalysis, summarize structural and bioinformatic approaches for identifying and classifying protein domains, and discuss the roles of protein domains as modules in the combinatorial evolution of protein structure and function.
Original language | English |
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Title of host publication | Encyclopedia of Cell Biology |
Subtitle of host publication | Volume 1-6, Second Edition |
Publisher | Elsevier |
Pages | 106-114 |
Number of pages | 9 |
Volume | 1 |
ISBN (Electronic) | 9780128216248 |
DOIs | |
State | Published - Jan 1 2022 |
Keywords
- Bioinformatics
- Catalysis
- Cryo-electron microscopy
- Crystallography
- Databases
- Nuclear magnetic resonance
- Protein domain
- Protein evolution
- Protein structure
- Protein–DNA interaction
- Protein–protein interaction
- Sequence motif