Protein Domains: Structure, Function, and Methods

David A. Korasick, Joseph M. Jez

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In the three-dimensional structure of proteins, domains are stably folded structural units that retain molecular function independent of the rest of the larger protein. Here we review the basic building blocks of protein structure, provide an overview of molecular functions of protein domains for macromolecular interactions, ligand binding, and catalysis, summarize structural and bioinformatic approaches for identifying and classifying protein domains, and discuss the roles of protein domains as modules in the combinatorial evolution of protein structure and function.

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
Subtitle of host publicationVolume 1-6, Second Edition
Number of pages9
ISBN (Electronic)9780128216248
StatePublished - Jan 1 2022


  • Bioinformatics
  • Catalysis
  • Cryo-electron microscopy
  • Crystallography
  • Databases
  • Nuclear magnetic resonance
  • Protein domain
  • Protein evolution
  • Protein structure
  • Protein–DNA interaction
  • Protein–protein interaction
  • Sequence motif


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