Summary: Protein disulfide isomerase (PDI) catalyzes disulfide bond oxidation, reduction and isomerization during protein synthesis in the endoplasmic reticulum (ER). In addition to its critical role in the ER, in vitro and in vivo studies with blocking antibodies and conditional knockout mice have demonstrated that cell surface PDI is required for thrombosis, hemostasis and vascular inflammation in a manner dependent on its isomerase activity. This review will focus on our current understanding of the pathophysiologic role of PDI in regulating integrin-mediated platelet and neutrophil functions during vascular disease.

Original languageEnglish
Pages (from-to)2084-2091
Number of pages8
JournalJournal of Thrombosis and Haemostasis
Issue number12
StatePublished - Dec 2013


  • Inflammation
  • Integrins
  • Neutrophils
  • Platelet
  • Protein disulfide isomerase
  • Thrombosis


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