TY - JOUR
T1 - Protein disulfide isomerase in cardiovascular disease
AU - Xiong, Bei
AU - Jha, Vishwanath
AU - Min, Jeong Ki
AU - Cho, Jaehyung
N1 - Funding Information:
We apologize to colleagues whose primary work was not cited because of space limitations. This work was supported by grants from the National Institutes of Health (R01HL130028, R01HL148280, and R01HL146559 to J.C.), the University of Illinois at Chicago Center for Clinical and Translational Science Award (UL1TR002003 to J.C.), and the Korea Research Institute of Bioscience and Biotechnology (J.K.M.).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Protein disulfide isomerase (PDI) participates in the pathogenesis of numerous diseases. Increasing evidence indicates that intravascular cell-derived PDI plays an important role in the initiation and progression of cardiovascular diseases, including thrombosis and vascular inflammation. Recent studies with PDI conditional knockout mice have advanced our understanding of the function of cell-specific PDI in disease processes. Furthermore, the identification and development of novel small-molecule PDI inhibitors has led into a new era of PDI research that transitioned from the bench to bedside. In this review, we will discuss recent findings on the regulatory role of PDI in cardiovascular disease.
AB - Protein disulfide isomerase (PDI) participates in the pathogenesis of numerous diseases. Increasing evidence indicates that intravascular cell-derived PDI plays an important role in the initiation and progression of cardiovascular diseases, including thrombosis and vascular inflammation. Recent studies with PDI conditional knockout mice have advanced our understanding of the function of cell-specific PDI in disease processes. Furthermore, the identification and development of novel small-molecule PDI inhibitors has led into a new era of PDI research that transitioned from the bench to bedside. In this review, we will discuss recent findings on the regulatory role of PDI in cardiovascular disease.
UR - http://www.scopus.com/inward/record.url?scp=85082804389&partnerID=8YFLogxK
U2 - 10.1038/s12276-020-0401-5
DO - 10.1038/s12276-020-0401-5
M3 - Review article
C2 - 32203104
AN - SCOPUS:85082804389
SN - 1226-3613
VL - 52
SP - 390
EP - 399
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 3
ER -