Protein arginine deiminase 2 binds calcium in an ordered fashion: Implications for inhibitor design

Keyphrases

• Inhibitor Design 100%
• Arginine Deiminase 100%
• Receptor-binding Domain 33%
• Dysregulated 33%
• Therapeutic Target 33%
• Breast Cancer Cells 33%
• Active Sites 33%
• Mass Spectrometry 33%
• Estrogen Receptor 33%
• Allosteric Inhibitor 33%
• Study Support 33%
• Regulatory Elements 33%
• Titration 33%
• X-ray Crystallography 33%
• Positioning Accuracy 33%
• Regulatory Process 33%
• Inflammatory Diseases 33%
• Calcium-dependent 33%
• Calcium Ion 33%
• Activation Mechanism 33%
• Enzyme Activation 33%
• Inflammation-associated Cancer 33%
• Coactivator 33%
• Citrullination 33%
• Hydrogen-deuterium Exchange 33%
• Arginine Residue 33%
• Histone-modifying Enzymes 33%
• Histone Tails 33%
• Catalytic Cysteine Residue 33%
• Estrogen Receptor Binding 33%
• Calcium Switch 33%
• Shielding Mechanism 33%

Biochemistry, Genetics and Molecular Biology

• Protein-Arginine Deiminase 100%
• Estrogen Receptor 66%
• Binding Site 33%
• Enzyme 33%
• Active Site 33%
• Cancer Cell 33%
• Mass Spectrometry 33%
• Regulatory Element 33%
• X-Ray Crystallography 33%
• Calcium Ion 33%
• Enzyme Activation 33%
• Hydrogen-Deuterium Exchange 33%
• Histone-Modifying Enzymes 33%
• Citrullination 33%
• Histone 33%
• Cysteine 33%
• Arginine 33%
• Receptor Binding 33%